Borgström, Björn (author); Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells; Doctoral thesis (other

Salinomycin (SAL) has been reported to exhibit anticancer response on various types of cancer. In the present study, we explored the antiangiogenic and anticancer efficacy of the polyether ionophore SAL in the breast cancer model. It effectively inhibited cell proliferation, invasion, and migration.

It effectively inhibited cell proliferation, invasion, and migration. In conclusion, the individual use of salinomycin and combined use with 17‑AAG may significantly inhibit SGC‑7901 gastric cancer cell proliferation and induce cell apoptosis. The potential mechanisms may be associated with upregulation of Fas‑L and downregulation of NF‑κB. Salinomycin is a carboxylic polyether ionophore extracted from Streptomyces albus(16). Salinomycin has been identified as a selective inhibitor of breast and lung CSCs (17,18), however its function in the inhibition of NPC CSCs remains to be revealed. Studies performed in 2011 showed that salinomycin could induce apoptosis of human cancer cells at higher concentrations. C20 amino derivatives such as ironomycin have shown to be more potent in vitro models of persister cancer cells and in vivo doi: 10.1038/nchem.2778.

Salinomycin cancer

Cancer stem cells are typically refractory to conventional treatments. Now, an unprecedented mechanism has been discovered by which salinomycin and derivatives can sequester iron in lysosomes Hypoxia and low pH are some of the major attributes of tumor milieu, enhancing anoikis evasion and therapy resistance. Several studies have shown that the therapeutic potential of small molecules (such as salinomycin) induced ROS production in cancer cells to inhibit anoikis resistance, invasiveness, migration, and metastasis (62, 90, 196–198 Angiogenesis plays a crucial role in tumor progression as it is required for sustained growth and metastasis, therefore targeting angiogenesis is a promising therapeutic approach for breast cancer management. Salinomycin (SAL) has been reported to exhibit anticancer response on various types of cancer.

Ett lever från kyckling, taget vid slakteri, innehöll salinomycin (coccidiostatika) contained salinomycin (coccidiostat) at a level above the maximum residue limit.

Adenocarcinoma cancers being usually in one of the following organs: prostate, breast, colon, If breast cancer is diagnosed at an early enough stage, it's treatable. There are a number of different treatments doctors recommend.

The thesis title is 'On the Breast Cancer Stem Cell Selectivity of Salinomycin and its Structural Analogues'. During the PhD study, I mainly focused on the effect of

The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. The antibiotic salinomycin, a potassium ionophore, has recently been shown to be a potent compound to deplete chemoresistant cells like cancer stem like cells (CSC) in adenocarcinomas. Here, we evaluated the effect of salinomycin on sarcoma cell lines, whereby salinomycin mono- and combination treatment with doxorubicin regimens were analyzed. Salinomycin (SAL) is one of the first discovered inhibitors of human cancer stem cells (CSCs), which acts via blocking the Wnt/β-catenin pathway. However, SAL has not been clinically used to treat human diseases due to its poor aqueous solubility and considerable toxicity. Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells.

Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain Gong Zhang , Shuping Zhang , Jinjin Ren , Chunxiao Yao , Zhongren Zhao , Xiurong Qi , Xiaofeng Zhang , Shuye Wang , and Lei Li In conclusion, the individual use of salinomycin and combined use with 17‑AAG may significantly inhibit SGC‑7901 gastric cancer cell proliferation and induce cell apoptosis.
Lon butikssaljare

C20 amino derivatives such as ironomycin have shown to be more potent in vitro models of persister cancer cells and in vivo doi: 10.1038/nchem.2778. Promising results from a few clinical pilot studies reveal that salinomycin is able to effectively eliminate cancer stem cells and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments Salinomycin has recently been shown to target CSCs in different types of human cancers, including gastric cancer , lung adenocarcinoma , osteosarcoma , colorectal cancer , squamous cell carcinoma (SCC) , and prostate CSCs , suggesting that salinomycin may be effective in CSCs of many, if not all, types of human cancers, although it is currently not known whether all cancers contain subpopulations of CSCs. Low-dose salinomycin inhibits breast cancer metastasis by repolarizing tumor hijacked macrophages toward the M1 phenotype 1.

Together we will beat cancer About cancer Cancer types Cancers in general Causes of cancer Coping with ca Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial 17 Aug 2017 Epithelial-mesenchymal transition (EMT) of cancer cells is widely accepted to be important for metastasis and progression, but it has also been “To investigate its action, we developed a surrogate salinomycin drug, ironomycin, that was at least 10-fold more potent than salinomycin against CSCs in vitro and 2 Aug 2016 In parallel, it works as an antagonist on ERα in breast cancer tissue where it inhibits tumor growth in estrogen dependent breast cancer [5]. 9 Aug 2011 Salinomycin, an antibiotic potassium ionophore, has been reported recently to act as a selective breast cancer stem cell inhibitor, but the 21 Jun 2013 cancer stem cells. We investigated the impact of salinomycin on survival, colony growth, migration and invasion of the differentiated human 20 May 2015 e13565 Background: Cancer stem cells (CSCs), a small population of tumor cells responsible for tumor seeding and recurrence, are Salinomycin is promising primarily because it has been shown to kill the cancer stem cells while at the same time enabling other drugs to more efficiently kill the 11 Aug 2015 Besides is wide effectiveness in various types of cancers, another strong point of Salinomycin is that even if it will not kill the cancer cells, it is a The in vitro anticancer activities of salinomycin have been validated against the lung cancer cell line A549 via sulforhodamine B and colony formation assay. In addition to your Primary Treatment(s), there are other ways to inhibit tumor that may contribute to the elimination of Cancer Stem Cells by salinomycin, says Información: Salinomicina: Nueva droga ataca a las células madre del cáncer Image comment: Cancer cells in tumors treated with salinomycin have a less 11 Mar 2021 In this podcast, Cancer.Net Associate Editor Dr. Norah Lynn Henry discusses new research presented at the 2020 San Antonio Breast Cancer 8 Apr 2020 Tumor phase: Tumors form on the skin.
Postoperative complications and management

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Salinomycin induces apoptosis of human colorectal cancer cells, accompanied by accumulation of dysfunctional mitochondria and reactive oxygen species. These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment.

These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment. 2019-11-13 · Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma Abstract. Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct Background. Uveal melanoma (UM) is the most common primary intraocular Salinomycin was originally used as an anticoccidial drug in poultry, and for efﬁcient nutrient absorption in piggery. Its preferential toxicity towards cancer-stem cells was described by Gupta and colleagues in the end of the last decade [1].